Study why diets high in vegetables and fruit protect
against the development of cancer.
- Currently we are studying the effects of diets
differing in vegetable and fruit content on biomarkers
of disease risk in a population of women either at
high risk for breast cancer or its recurrence.
- Two questions dominate our current research agenda:
1) what intake of vegetables and fruit is adequate
to confer protection, and 2) from which botanical
families of vegetables and fruit are the most potent
protective effects derived.
Study how reducing caloric intake or increasing physical
activity can lead to a reduction in risk for cancer.
- Our current focus is on the use of caloric restriction
and exercise to prevent breast cancer.
- Caloric restriction is the most powerful, physiological,
non detrimental approach to cancer prevention that
has ever been identified.
- Physical inactivity has recently been implicated
as a major factor influencing cancer risk in human
populations around the world.
- We are determining the chemical basis underlying
the potent preventive activity of weight control and
physical activity so that we can use the knowledge
to develop practical, safe and effective approaches
to prevent cancer and other diseases.
Study whether daily consumption of a dietary supplement
containing selenium reduces the risk
- Two clinical trials are ongoing. One is in a population
of men at increased risk for lung cancer and the other
is in a population of women at risk for breast cancer
because of a family history of the disease.
Identify modifiable risk factors for cancer that
can be monitored periodically to follow changes in cancer
- We are currently working with three populations
of women who are at low, intermediate, and high risk
for breast cancer. Efforts are ongoing to identify
circulating chemicals that reflect an individual’s
risk for cancer. We will then proceed to target the
gene(s) involved in the production of these chemicals
with drug-based intervention tailored to reduce cancer