Cytokeratin 14 expression in normal mammary gland, Intraductal Proliferations (IDP) and adenocarcinomas (AC)

references (PubMed)

Click on image to enlarge
 
ck14 skin control lp copy.JPG (31380 bytes)

Normal rat skin used as control (low power)

 

 

  ck14 skin control hp.JPG (30528 bytes)

Normal rat skin used as control (high power) showing a single hair follicle with sebaceous gland. Note that only the basal layer of skin is positive for cytokeratin 14.

 

ck14 normal breast  lp copy.JPG (25772 bytes)

Normal rat mammary gland (low power)

 

  ck14 normal breast  hp.JPG (17757 bytes)

Normal rat mammary gland (high power). Note that only the myoepitheilal cells are stained and not the mammary epithelial cells.

 

ck14 breast IDP1 lp copy.JPG (25484 bytes)

IDP (low power)

  ck14 breast IDP1 hp.JPG (35154 bytes)

IDP (high power)
Note staining of most, but no all secondary lumina.

 

ck14 breast IDP2 lp copy1.JPG (32183 bytes)

IDP (low power)

 

  ck14 breast IDP3 hp.JPG (23849 bytes)

IDP (high power)
Note the lack of staining in the secondary
lumina with just a few "hot spot" areas in between.

 

ck14 breast AC1 lp copy.JPG (35693 bytes)

AC (low power)

 

  ck14 breast AC1 hp.JPG (32817 bytes)

AC (high power).
Note overall  intense staining pattern. Not
every cell is staining. However, there appear to be clusters that create a "honeycomb" effect.

 

ck14 breast AC2 lp copy.JPG (37891 bytes)

AC (low power)

 

  ck14 breast AC2 hp.JPG (29503 bytes)

AC (high Power)
Staining pattern remains intense, but very
disorganized.

Colorado State University CHOICE BreastWatch