Angiogenesis in premalignant disease

IDP Mild | IDP Moderate | IDP Florid | DCIS
(click on the links above to see examples)

Angiogenesis in malignant disease

Below is an example of a mammary adenocarcinoma that has been stained with CD31 (PECAM) to identify blood vessels.
     


Original lesion

 
Lesion epithelium circumscribed in green with a 50 µm border extending out from the periphery.
     

J: Extra-tumoral blood vessels are indicated in yellow
while intra-tumoral vessels, i.e. those within the green region are marked in fuschia.

 

K: Stromal invagination with intratumoral vessels marked in fuschia. The black line indicates the seaparation point between intra- and extra-tumoral.

 

L: Increased collagan deposition with multiple foci of lesion epithelium. Black lines indicate seaparation point between intra- and extra-tumoral.

 

Colorado State University CHOICE BreastWatch